Nonclinical Services


Pathological Examination

In LSIM Safety Institute, pathological examinations are conducted by pathologists who are board-certified by the Japanese Society of Toxicologic Pathology (JSTP) and recognized as experts by the Japanese College of Veterinary Pathologists (JCVP) while our numerous histological technicians, all certified by the Japanese Association of Histotechnology (JAH), prepare tissue specimens of hematoxylin and eosin staining, special stains and immunostaining according to our clients’ needs. We carry out various safety studies or efficacy pharmacological tests using rats, mice, guinea pigs, rabbits, dogs, monkeys, mini pigs, etc., and each pathological examination is conducted by experienced and knowledgeable pathologists. According to our clients’ needs, we are also able to provide histopathological examination of formalin-fixed tissues that are sent to us, or preparation of histopathological specimens only. We are able to offer our clients high-quality pathological results through the abundant experience and knowledge of our pathologists and histological technicians.

Pathology Services

  • Pathology only services (from receipt of fixed tissues to microscopic examination)
  • Preparation of histopathological specimens (from receipt of fixed tissues to preparation)
  • Immunostaining

Measurement of Hormone Biomarkers

LSIM Safety Institute conducts measurement of hormones and biomarkers of various experimental animals by RIA and EIA methods. All of these measurements are conducted at our pharmaceutical GLP compliant facility and may be performed in compliance with GLP regulations upon request. We have a wide range of background data such as estrous cycles, circadian rhythm, and age-related changes, etc. Please feel free to inquire about the items including those not listed below.

Services Available

  • Pituitary hormone (ACTH, LH, FSH, GH, prolactin, TSH, etc.)
  • Thyroid hormone (T3, T4, PTH, etc.)
  • Adrenocortical hormone (cortisol, corticosterone, aldosterone, etc.)
  • Sex hormone (testosterone, dihydrotestosterone, estradiol, progesterone, etc.)
  • Renal function marker (β2-macroglobulin, albumin)
  • Inflammatory or tumor marker (cytokine, eicosanoid, etc.)
  • Anemia or bleeding marker (hemoglobin, transferrin, ferritin, etc.)
  • Bone metabolism marker (osteocalcin, urinary deoxypyridinoline, etc.)
  • Immunoglobulin, blood pressure or heart function marker, etc.

Contact Us

We provide information for clients concerning development of pharmaceuticals, agrichemicals, and chemical substances etc.
Please note and understand that we cannot respond to requests from competitors or free e-mail addresses.

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