In LSIM Safety Institute, safety pharmacology studies on pharmaceuticals, medical equipment, regenerative medicine products, etc. can be conducted under various GLP and/or guidelines. Most of the animal laboratory personnel who are qualified as laboratory animals 1st, 2nd grade technicians or JACL certified technicians, have highly reliable technique based on abundant experience, and have quick and detailed analysis ability.
●Central nervous system
1Effect on general activity and behavior (Modified Irwin's method/FOB)
2Effect on spontaneous locomotive activity
3Effect on body temperature
1Effect on the blood pressure, heart rate and ECG in conscious and unrestrained dogs or monkeys (Telemetry method)
2Effect on Ikr current (Whole cell/patch clamp method; hERG transduced cells) (Under room temperature or 37 °C conditions)
1Effect on the respiratory rate and tidal volume in conscious and unrestrained animals (Whole Body Plethysmography)
2Effect on the respiratory rate and Arterial oxygen saturation (pulse oximeter) in conscious and unrestrained animals
* To comply with safety pharmacology studies on regenerative medicine products, effects on the central nervous system (Modified Irwin's method), blood pressure and heart rate (Tail cuff method) and respiratory function (Whole body plethysmography) can be evaluated by using NOG mice and NOD SCID mice.
1.3Supplemental Safety Pharmacology Studies
We provide information for clients concerning development of pharmaceuticals, agrichemicals, and chemical substances etc.
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